William A. Werbel, MD, PhD

Associate Professor of Medicine · Division of Infectious Diseases

Johns Hopkins University School of Medicine

Dr. Werbel is a physician-scientist focused on optimizing protection against infections for immunosuppressed persons, leading clinical trials and national studies of respiratory viral vaccinations for transplant recipients and other immunosuppressed populations.

About Dr. Werbel

William A. Werbel, MD, PhD is an Associate Professor of Medicine in the Division of Infectious Diseases at Johns Hopkins University School of Medicine, with a joint appointment in Epidemiology at the Johns Hopkins Bloomberg School of Public Health. He serves as the Associate Director for Epidemiology and Quantitative Sciences in the Johns Hopkins Transplant Research Center.

Dr. Werbel's research focuses on optimizing protection against infections for immunosuppressed persons using a combination of epidemiological and laboratory approaches. He leads clinical trials and national studies of respiratory viral vaccinations for transplant recipients and other immunosuppressed populations.

Following MD training at the University of Michigan and internal medicine residency and chief residency at Northwestern University, he completed fellowships in infectious diseases as well as a PhD in Clinical Investigation at Johns Hopkins. His work bridges clinical practice and translational research to improve outcomes for some of the most vulnerable patient populations.

Education & Professional Credentials

Doctor of Medicine (MD)

University of Michigan

PhD in Clinical Investigation

Johns Hopkins University

Internal Medicine Residency & Chief Residency

Northwestern University

Fellowship in Infectious Diseases

Johns Hopkins University

Areas of Expertise

Transplant Infectious Diseases

Specialized care for transplant recipients navigating complex infectious disease risks during immunosuppression.

  • Pre- and post-transplant infection management

  • Opportunistic infection prevention

  • Donor-derived infection risk assessment

Oncology Infectious Diseases

Managing infectious complications in cancer patients undergoing immunosuppressive therapies and treatments.

  • Infection prevention during chemotherapy

  • Antimicrobial stewardship in oncology

  • Post-treatment immune reconstitution

Vaccine Research for Immunosuppressed Populations

Leading clinical trials to optimize vaccination strategies for patients whose immune systems are compromised.

  • Respiratory viral vaccine clinical trials

  • Immune response measurement in transplant recipients

  • National multi-site vaccination studies

Clinical Epidemiology

Applying epidemiological methods to understand and reduce infection risk in vulnerable populations.

  • Population-level infection surveillance

  • Risk factor identification and modeling

  • Outcomes research in immunosuppressed cohorts

Respiratory Viral Infections

Studying respiratory virus transmission, prevention, and treatment in high-risk immunocompromised patients.

  • COVID-19, influenza, and RSV in transplant patients

  • Antiviral treatment optimization

  • Prophylaxis and infection control strategies

Translational Laboratory Research

Bridging bench-to-bedside research to develop improved diagnostic and therapeutic approaches for immunosuppressed patients.

  • Immune correlates of vaccine protection

  • Serological and cellular immune profiling

  • Biomarker development for infection risk

What You'll Learn

Vaccination Strategies for Immunosuppressed Patients

Evidence-based approaches to optimizing vaccine timing, dosing, and selection for transplant recipients and cancer patients with compromised immune systems.

Understanding Immune Response After Treatment

How cancer therapies affect the immune system's ability to fight infections, and what survivors need to know about immune reconstitution and long-term protection.

Infection Prevention in Cancer Care

Practical strategies for reducing infectious complications during and after cancer treatment, including prophylaxis, screening, and early intervention approaches.

Latest Clinical Trial Insights

Emerging findings from national vaccination studies and clinical trials that are shaping the future of infection prevention for immunocompromised populations.

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